The ANT-44 was designed as a long-range maritime reconnaissance, incorporated four 604 kW Gnome-Rhône Mistral Major 14Kdrs M-85, radial engines. The initial design employed an all-metal construction with a shoulder-mounted semi-gull wing. A month of factory trials changed the Mistral Major, radial engines. The second prototype designated ANT-44D and ANT-44bis, an amphibious aircraft. Both aircraft were pressed in the Black Sea region into service.